Scientist – Protein Engineering / Directed Evolution

About Us:

Portal Biotech is a high-tech, fast growing startup company pioneering the development of next-generation single-molecule biosensors for proteomic and metabolomic analysis. Our purpose is to revolutionize the detection of biologically critical proteomic and metabolomic biomarkers to drive advances in healthcare and the wider life sciences. Our team consists of passionate scientists, engineers, and professionals driven by a shared mission to revolutionize human health, technology and biology. We are realizing this through the development of the company’s cutting-edge proprietary nanopore technology, which is an emerging single-molecule biosensing technology that is uniquely capable of addressing a wide range of unmet needs across the life sciences.

Position Overview:

We are currently seeking a talented and motivated Protein Engineer with expertise in Enzyme Design and Directed Evolution Techniques to join our dynamic team. The selected candidate will play a key role in our research and development efforts, contributing to the discovery and development of novel technologies in proteomics and metabolomics. As a Scientist you will be responsible for the (re-)design and engineering of enzymes, production and screening of enzyme variants and libraries. The role will involve designing and executing directed evolution campaigns, among other enzyme engineering strategies, and chemical modification of proteins to achieve these objectives. Additionally, the Scientist will be encouraged to identify and explore alternative enzymatic or chemical routes for our technology.

Responsibilities:

• Design and conduct experiments utilizing directed evolution and related techniques to investigate and improve the physicochemical properties and the activity of enzymes.
• Chemical and enzymatical modification of proteins.
• Analyze and interpret experimental data, and present findings to internal teams.
• Collaborate with cross-functional teams to support project goals and milestones.
• Contribute to the development and optimization of experimental protocols and methodologies.
• Stay abreast of advancements in enzyme engineering and related fields, and integrate new technologies and techniques into research efforts.

Requirements:

• Ph.D. or equivalent experience in biochemistry, or related field.
• Strong background in enzyme engineering. Hands-on experience in biochemistry and enzyme design techniques is essential.
• Proficiency in data analysis, with experience using software for protein structure analysis.
• Excellent communication skills, with the ability to effectively collaborate within multidisciplinary teams.
• Track record of independent research, demonstrated through publications, presentations, or other means.
• Highly motivated, with a passion for scientific discovery and innovation.

Benefits:

Portal is an equal opportunities employer. We are enriched by our diversity and are committed to creating and sustaining an inclusive and equitable environment for all. We are a values-led enterprise, and the dedication, passion, and enthusiasm of our talented employees is our cornerstone. We strive to create an environment where our team feel empowered to be their best selves, and where they enjoy working and building both the technologies and our company with us.

Employees receive a competitive salary, 25 days of holiday plus bank holidays, and the opportunity to participate in our share option scheme.

Reach out if you are curious, committed and collaborative, are interested in developing the next generation of biosensing technology.

How to Apply:

Interested candidates should submit a cover letter, CV, and contact information for references to careers-nl@portalbiotech.com. Please include “Scientist – Protein Engineering/Directed Evolution NL” in the subject line of your email. Applications will be reviewed on a rolling basis until the position is filled.

At Portal Biotech, we believe diversity drives innovation and are committed to fostering an inclusive workplace where all individuals are valued and empowered. We encourage applications from candidates of all backgrounds and experiences.

Join us in our mission to transform healthcare through groundbreaking research and innovation. Apply today!